Article
Flow cytometry evaluation of the multidrug-resistant phenotype with functional tests involving uptake of daunorubicin, Hoechst 33342, or rhodamine 123: a comparative study.
Cancer detection and prevention - 1 Jan 1995
Lizard G, Roignot P, Maynadie M, Lizard-Nacol S, Poupon M F, Bordes M
Abstract excerpt
Multidrug-resistant (MDR) cells are characterized by a defect in drug accumulation caused by overexpression of a transmembrane glycoprotein, the P-glycoprotein (P-gp). The MDR phenotype can be characterized either by use of monoclonal antibodies raised against P-gp or with functional tests based...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibiotics, Antineoplastic
- Antimetabolites, Antineoplastic
- Benzimidazoles
- Cell Death
- Daunorubicin
- Drug Resistance, Multiple
- Flow Cytometry
- Hot Temperature
- Humans
- Phenotype
- Rhodamine 123
- Rhodamines
- Tumor Cells, Cultured