Article
Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms.
Pharmacogenetics - 1 Jun 2004
Meissner Konrad, Jedlitschky Gabriele, Meyer zu Schwabedissen Henriette, Dazert Peter, Eckel Lothar, Vogelgesang Silke, Warzok Rolf W, Böhm Michael, Lehmann Christian, Wendt Michael, Cascorbi Ingolf, Kroemer Heyo K
Abstract excerpt
OBJECTIVES: Variable expression of the ABC-type multidrug resistance membrane protein P-glycoprotein (P-gp, MDR1, ABCB1) in human heart is a potential modulator of drug effects or drug-induced cardiotoxicity. Expression of P-gp is known to be affected by single nucleotide polymorphisms in the MDR1 gene. Therefore, genotype-dependent expression of P-gp could be an important modulator of action of cardiac drugs....
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