Article
Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age.
Mutation research - 1 Oct 1995
Ono T, Miyamura Y, Ikehata H, Yamanaka H, Kurishita A, Yamamoto K, Suzuki T, Nohmi T, Hayashi M, Sofuni T
Abstract excerpt
Spontaneous mutant frequency of lacZ gene in spleen of transgenic MutaTM mouse was examined at different ages. It was (3.2 +/- 1.3 (SD)) x 10(-5) at newborn and increased almost linearly with age up to (8.3 +/- 1.8) x 10(-5) at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and...
Topics
- Aging
- Animals
- Female
- Hypoxanthine Phosphoribosyltransferase
- Lac Operon
- Male
- Mice
- Mice, Transgenic
- Mutation
- Spleen
- Transgenes