Article
Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 1996
Douglas G R, Jiao J, Gingerich J D, Soper L M, Gossen J A
Abstract excerpt
In order to help establish criteria for optimizing protocols for in vivo mutation studies, lacZ transgenic mice (Muta mouse) were treated with five consecutive daily doses of ethylnitrosourea (50 mg/kg), sampled at times up to 55 days after treatment, and mutant frequencies and DNA sequences dete...
Topics
- Animals
- Bone Marrow
- Ethylnitrosourea
- Liver
- Mice
- Mice, Transgenic
- Mutagenicity Tests
- Mutagens
- Mutation
- Sequence Analysis, DNA
- Time Factors
- Tissue Fixation
- beta-Galactosidase