Article
Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 1996
Douglas G R, Jiao J, Gingerich J D, Soper L M, Gossen J A
Abstract excerpt
In order to help establish criteria for optimizing protocols for in vivo mutation studies, lacZ transgenic mice (Muta mouse) were treated with five consecutive daily doses of ethylnitrosourea (50 mg/kg), sampled at times up to 55 days after treatment, and mutant frequencies and DNA sequences determined for liver and bone marrow. In the bone marrow, the mutant frequency rose very rapidly in the first 5 days after...
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