Article
Tissue-specific and time-dependent clonal expansion of ENU-induced mutant cells in gpt delta mice.
Environmental and molecular mutagenesis - 1 Oct 2017
Nakayama Takafumi, Sawai Tomoko, Masuda Ikuko, Kaneko Shinya, Yamauchi Kazumi, Blyth Benjamin J, Shimada Yoshiya, Tachibana Akira, Kakinuma Shizuko
Abstract excerpt
DNA mutations play a crucial role in the origins of cancer, and the clonal expansion of mutant cells is one of the fundamental steps in multistage carcinogenesis. In this study, we correlated tumor incidence in B6C3F1 mice during the period after exposure to N-ethyl-N-nitrosourea (ENU) with the persistence of ENU-induced mutant clones in transgenic gpt delta B6C3F1 mice. The induced gpt mutations afforded no...
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