Article
Transmission of mutations in the lacI transgene to the offspring of ENU-treated Big Blue male mice.
Environmental and molecular mutagenesis - 1 Jan 2002
Barnett Lois B, Tyl Rochelle W, Shane Barbara S, Shelby Michael D, Lewis Susan E
Abstract excerpt
The purpose of the study was to determine: 1) if male germ cells of Big Blue mice carrying newly induced mutations in the lacI transgene were effective in fertilization; 2) if offspring arising from such mutant sperm had the mutation in germ cells and multiple somatic tissues; and 3) how the frequency of mutants induced in the lacI transgene compared to the frequency induced in endogenous genes traditionally...
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