Article
Benzo[b]fluoranthene: tumorigenicity in strain A/J mouse lungs, DNA adducts and mutations in the Ki-ras oncogene.
Carcinogenesis - 1 Aug 1996
Mass M J, Abu-Shakra A, Roop B C, Nelson G, Galati A J, Stoner G D, Nesnow S, Ross J A
Abstract excerpt
The polycyclic aromatic hydrocarbon benzo[b]fluoranthene (B[b]F) is a pervasive constituent of environmental combustion products. We sought to examine the lung tumorigenic activity of B[b]F in strain A/J mice, to study the relationship between formation and decay of B[b]F-DNA adducts and to exami...
Topics
- Animals
- Base Sequence
- DNA Adducts
- DNA Primers
- Fluorenes
- Genes, ras
- Lung
- Lung Neoplasms
- Male
- Mice
- Molecular Sequence Data
- Mutation