Article
Ki-ras mutations are an early event and correlate with tumor stage in transplacentally-induced murine lung tumors.
Carcinogenesis - 1 Jun 1997
Leone-Kabler S, Wessner L L, McEntee M F, D'Agostino R B, Miller M S
Abstract excerpt
A previous study from this laboratory demonstrated that treatment of pregnant mice with 3-methylcholanthrene (MC) caused lung tumors in the offspring at 1 year after birth, the incidence of which correlated with fetal inducibility of Cyp1a1. Analysis by PCR amplification and allele-specific hybri...
Topics
- Animals
- Blotting, Northern
- Carcinogens
- Cytochrome P-450 CYP1A1
- Female
- Genes, ras
- Lung Neoplasms
- Male
- Maternal-Fetal Exchange
- Methylcholanthrene
- Mice
- Mice, Inbred DBA
- Mutation
- Neoplasm Staging
- Phenotype
- Pregnancy
- Prenatal Exposure Delayed Effects
- RNA, Neoplasm