Article
Ki-ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J mice.
Molecular carcinogenesis - 1 Jan 1993
Mass M J, Jeffers A J, Ross J A, Nelson G, Galati A J, Stoner G D, Nesnow S
Abstract excerpt
Strain A/J mice received intraperitoneal injections of benz[j]aceanthrylene (B[j]A) or benzo[a]pyrene (B[a]P). At 24, 48, and 72 h, lung tissues were removed for analysis of B[a]P- or B[j]A-derived DNA adduct formation during the first 3 d of exposure. One group of mice exposed to these hydrocarbons was kept for 8 mo to determine lung tumor multiplicity, the occurrence of mutations in codons 12 and 61 of the...
Topics
- Animals
- Base Sequence
- Benzo(a)pyrene
- DNA
- Genes, ras
- Lung Neoplasms
- Methylcholanthrene
- Mice
- Mice, Inbred A
- Molecular Sequence Data
- Mutation