Article
Frequent mutations of Ki-ras but no mutations of Ha-ras and p53 in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Molecular carcinogenesis - 1 Apr 1996
Kitada H, Tsutsumi M, Tsujiuchi T, Takahama M, Fukuda T, Narita N, Konsihi Y
Abstract excerpt
Point mutations of the Ki-ras and p53 genes in rat lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) were investigated by polymerase chain reaction-single strand conformation polymorphism analysis followed by direct sequencing using paraffin-embedded tissues. Male Wistar rats 6 wk...
Topics
- Adenocarcinoma
- Animals
- Base Sequence
- Carcinoma, Squamous Cell
- DNA Primers
- Genes, p53
- Genes, ras
- Lung Neoplasms
- Male
- Molecular Sequence Data
- Mutagens
- Mutation
- Nitrosamines
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins p21(ras)
- Rats
- Rats, Wistar
- Tumor Suppressor Protein p53