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Article

Frequent mutations of Ki-ras but no mutations of Ha-ras and p53 in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats.

Molecular carcinogenesis - 1 Apr 1996

Kitada H, Tsutsumi M, Tsujiuchi T, Takahama M, Fukuda T, Narita N, Konsihi Y

Abstract excerpt

Point mutations of the Ki-ras and p53 genes in rat lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) were investigated by polymerase chain reaction-single strand conformation polymorphism analysis followed by direct sequencing using paraffin-embedded tissues. Male Wistar rats 6 wk old were given 2000 ppm BHP in drinking water for 15 wk. Another group was given drinking water without BHP. The rats...

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Identifiers

PMID: 8634086
DOI: 10.1002/(SICI)1098-2744(199604)15:4<276::AID-MC5>3.0.CO;2-E

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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