Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.

Japanese journal of clinical oncology - 1 Oct 1996

Kanaoka S, Hanai H, Kaneko E, Kino I, Baba S, Fujita M

Abstract excerpt

It is currently accepted that colorectal tumorigenesis results from accumulation of multiple mutations in certain genes. This concept prompted us to search for possible mutations in the APC, k-ras, and p53 genes in an advanced cancer coexisting with a large villous adenoma of the rectum in a 54-year-old patient with no family history of colorectal cancer. Genomic DNA extracted from multiple subregions of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APC gene
Share to Genes, APC

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genes, ras

Share to Mutation

Share to Neoplasms, Multiple Primary

Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 8895682
DOI: 10.1093/oxfordjournals.jjco.a023250

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.PMID 8895682Read ↗

Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP).Semantic proximity Read ↗

K-ras mutation in a tubular adenoma originating at an ileostomy in a familial adenomatous polyposis patient.Semantic proximity Read ↗

APC and p53 mutations in de novo colorectal adenocarcinomas.Semantic proximity Read ↗

No evidence for overexpression of the p53 protein and mutations in exons 4-9 of the p53 gene in a large family with adenomatous polyposis.Semantic proximity Read ↗

Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and sporadic colorectal tumors.Semantic proximity Read ↗

Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.Semantic proximity Read ↗

Frequent lack of GNAS mutations in colorectal adenocarcinoma associated with GNAS-mutated villous adenoma.Semantic proximity Read ↗

Genetic alterations in the adenoma--carcinoma sequence.Semantic proximity Read ↗

Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.Semantic proximity Read ↗

[The significance of p53 gene mutations and expressions in human colorectal tumors].Semantic proximity Read ↗

Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations.Semantic proximity Read ↗

Association of APC gene mutations and histological characteristics of colorectal adenomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.