Article
Genetic alterations in the adenoma--carcinoma sequence.
Cancer - 15 Sept 1992
Cho K R, Vogelstein B
Abstract excerpt
Tumorigenesis is thought to be a multistep process in which genetic alterations accumulate, ultimately producing the neoplastic phenotype. A model was proposed to explain the genetic basis of colorectal neoplasia that included several salient features. First, colorectal tumors appear to occur as...
Topics
- Adenoma
- Alleles
- Carcinoma
- Cell Adhesion Molecules
- Chromosome Deletion
- Colorectal Neoplasms
- Genes, Tumor Suppressor
- Genes, ras
- Humans
- Models, Genetic
- Mutation