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Article

APC and p53 mutations in de novo colorectal adenocarcinomas.

Human mutation - 1 Jan 1994

Aoki T, Takeda S, Yanagisawa A, Kato Y, Ajioka Y, Watanabe H, Kudo S, Nakamura Y

Abstract excerpt

To investigate genetic features in small and flat colorectal carcinomas that arise de novo, we searched for genetic alterations in six sporadic tumors by examining their APC, K-ras, and p53 genes. Two of the six tumors carried detectable mutations within the mutation cluster region (MCR) of the APC gene; both mutations were predicted to cause truncation of the gene product. Four tumors carried mutations of the...

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Identifiers

PMID: 8081386
DOI: 10.1002/humu.1380030403

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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