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Article

APC and p53 mutations in de novo colorectal adenocarcinomas.

Human mutation - 1 Jan 1994

Aoki T, Takeda S, Yanagisawa A, Kato Y, Ajioka Y, Watanabe H, Kudo S, Nakamura Y

Abstract excerpt

To investigate genetic features in small and flat colorectal carcinomas that arise de novo, we searched for genetic alterations in six sporadic tumors by examining their APC, K-ras, and p53 genes. Two of the six tumors carried detectable mutations within the mutation cluster region (MCR) of the A...

Topics

Adenocarcinoma
Aged
Colorectal Neoplasms
DNA Mutational Analysis
Female
Genes, APC
Genes, p53
Genes, ras
Humans
Male
Middle Aged
Mutation
Point Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Sequence Deletion

Source

Identifiers

PMID: 8081386
DOI: 10.1002/humu.1380030403

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8081386-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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