Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.

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Article

Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.

Oncogene - 1 Nov 1993

Williams A C, Browne S J, Yeudal W A, Paterson I C, Marshall C J, Lane D P, Paraskeva C

Abstract excerpt

The aim of the current study was to identify genetic abnormalities in human colorectal adenoma and carcinoma derived cell lines, and to determine whether the genetic changes which occur in vitro are relevant to the in vivo situation. Loss of 1p(33-35) region was shown to be the most common chromo...

Topics

Adenocarcinoma
Adenoma
Base Sequence
Chromosome Deletion
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 18
Colorectal Neoplasms
Genes, p53
Genes, ras
Humans
Molecular Sequence Data
Mutation
Tumor Cells, Cultured
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8414507

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8414507-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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