Article
Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and sporadic colorectal tumors.
Princess Takamatsu symposia - 1 Jan 1991
Nakamura Y, Nishisho I, Kinzler K W, Vogelstein B, Miyoshi Y, Miki Y, Ando H, Horii A, Nagase H
Abstract excerpt
We have isolated several genes in the chromosome 5q21 region tightly linked to hereditary familial polyposis coli (FAP) and Gardner's syndrome (GS). Two of these genes (MCC and APC) were found to be somatically altered by point mutation, deletion or insertion in tumors of sporadic colorectal cancer patients. One of them (adenomatous polyposis coli; APC) was also found to mutate in the germ-line of both APC and GS...
Topics
- Adenomatous Polyposis Coli
- Base Sequence
- Colorectal Neoplasms
- Gardner Syndrome
- Genes, APC
- Genes, MCC
- Humans
- Molecular Sequence Data
- Mutation