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Article

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 1997

Barnes G, Rio D

Abstract excerpt

In mammalian cells, the Ku heterodimer is involved in DNA double-strand-break recognition and repair. We have established in yeast a connection between Ku activity and DNA double-strand-break damage repair, and a connection between Ku activity and commitment to DNA replication. We generated double-stranded DNA breaks in yeast cells in vivo by expressing a restriction endonuclease and have shown that yeast mutants...

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Identifiers

PMID: 9023348
DOI: 10.1073/pnas.94.3.867
PMCID: PMC19605

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