Article
Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.
Molecular and cellular biology - 1 Nov 2011
Foster Steven S, Balestrini Alessia, Petrini John H J
Abstract excerpt
The Mre11 complex is a central component of the DNA damage response, with roles in damage sensing, molecular bridging, and end resection. We have previously shown that in Saccharomyces cerevisiae, Ku70 (yKu70) deficiency reduces the ionizing radiation sensitivity of mre11Δ mutants. In this study, we show that yKu70 deficiency suppressed the camptothecin (CPT) and methyl methanesulfonate (MMS) sensitivity of...
Topics
- DNA Breaks, Double-Stranded
- DNA Damage
- DNA End-Joining Repair
- DNA Replication
- DNA, Fungal
- DNA-Binding Proteins
- Endodeoxyribonucleases
- Endonucleases
- Exodeoxyribonucleases
- Flap Endonucleases
- Genes, Fungal