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Article

Telomere-related functions of yeast KU in the repair of bleomycin-induced DNA damage.

Biochemical and biophysical research communications - 8 Jun 2007

Tam Angela T Y, Pike Brietta L, Hammet Andrew, Heierhorst Jörg

Abstract excerpt

Bleomycins are small glycopeptide cancer chemotherapeutics that give rise to 3'-modified DNA double-strand breaks (DSBs). In Saccharomyces cerevisiae, DSBs are predominantly repaired by RAD52-dependent homologous recombination (HR) with some support by Yku70/Yku80 (KU)-dependent pathways. The main DSB repair function of KU is believed to be as part of the non-homologous end-joining (NHEJ) pathway, but KU also...

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Source

Identifiers

PMID: 17442269
DOI: 10.1016/j.bbrc.2007.04.011

Genes

RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Telomere-related functions of yeast KU in the repair of bleomycin-induced DNA damage.PMID 17442269Read ↗

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance.Semantic proximity Read ↗

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Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug BleomycinSemantic proximity Read ↗

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Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining.Semantic proximity Read ↗

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Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae.Semantic proximity Read ↗

Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeast.Semantic proximity Read ↗

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences.Semantic proximity Read ↗

The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini.Semantic proximity Read ↗

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