Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences.

Molecular and cellular biology - 1 Dec 2003

Ma Jia-Lin, Kim Eun Mi, Haber James E, Lee Sang Eun

Abstract excerpt

End joining of double-strand breaks (DSBs) requires Ku proteins and frequently involves base pairing between complementary terminal sequences. To define the role of terminal base pairing in end joining, two oppositely oriented HO endonuclease cleavage sites separated by 2.0 kb were integrated into yeast chromosome III, where constitutive expression of HO endonuclease creates two simultaneous DSBs with no...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Nuclear
Share to Chromosome Breakage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Ligase ATP

Share to DNA Ligases

Share to Endodeoxyribonucleases

Share to Exodeoxyribonucleases

Share to Ku Autoantigen

Share to Rad52 DNA Repair and Recombination Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 14612421
DOI: 10.1128/MCB.23.23.8820-8828.2003
PMCID: PMC262689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences.PMID 14612421Read ↗

Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae.Semantic proximity Read ↗

MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings.Semantic proximity Read ↗

Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.Semantic proximity Read ↗

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae.Semantic proximity Read ↗

The pendulum of the Ku-Ku clockSemantic proximity Read ↗

Exonuclease 1-dependent and independent mismatch repair.Semantic proximity Read ↗

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Semantic proximity Read ↗

Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres.Semantic proximity Read ↗

Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae.Semantic proximity Read ↗

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability.Semantic proximity Read ↗

Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance.Semantic proximity Read ↗

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break RepairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.