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Article

Requirement for increased IL-10 in the development of B-1 lymphoproliferative disease in a murine model of CLL.

15 Oct 1996

Abstract excerpt

Malignant B-1 cells derived from NZB mice, a murine model of spontaneous autoimmunity and B cell lymphoproliferative disease, produce significantly higher levels of IL-10 mRNA than normal B-1 or B cells. IL-10 may act as an autocrine growth factor for the expansion of malignant B-1 cells. In order to determine if elevated endogenous production of IL-10 was a required element for the malignant transformation of...

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Identifiers

PMID: 8878429
DOI: 10.1172/jci118978

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