Unexpected development of autoimmunity in BAFF-R-mutant MRL-lpr mice.

doi:10.1111/j.1365-2567.2006.02500.x

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Article

Unexpected development of autoimmunity in BAFF-R-mutant MRL-lpr mice.

Immunology - 1 Feb 2007

Ju Zhong L, Shi Gui Y, Zuo Jin X, Zhang Jing W

Abstract excerpt

BAFF-R is the predominant receptor that mediates B-cell activating factor (BAFF)-dependent B-cell signalling and plays a critical role in late-stage B-cell maturation and survival. BAFF has been implicated in the development of autoimmunity and systemic lupus erythematosus (SLE). To define the role of BAFF-R in autoimmunity and SLE, we crossed A/WySnJ mice with MRL-lpr mice and generated BAFF-R-mutant MRL-lpr...

Topics

Animals
Antibody-Producing Cells
Autoantibodies
Autoimmunity
B-Cell Activation Factor Receptor
B-Lymphocytes
Bone Marrow
Cell Proliferation
Cells, Cultured
Germinal Center
Glomerulonephritis
Hypergammaglobulinemia
Immune Complex Diseases
Immunoglobulin G
Immunoglobulin M
Lupus Erythematosus, Systemic
Mice
Mice, Inbred MRL lpr

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Identifiers

PMID: 17073941
DOI: 10.1111/j.1365-2567.2006.02500.x
PMCID: PMC2265857

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