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Article

Susceptibility alleles for aberrant B-1 cell proliferation involved in spontaneously occurring B-cell chronic lymphocytic leukemia in a model of New Zealand white mice.

Blood - 15 Nov 1998

Hamano Y, Hirose S, Ida A, Abe M, Zhang D, Kodera S, Jiang Y, Shirai J, Miura Y, Nishimura H, Shirai T

Abstract excerpt

B-cell chronic lymphocytic leukemia (B-CLL) and autoimmune disease are a related event, and genetic factors are linked to both diseases. As B-CLL is mainly of B-1 cell type that participates in autoantibody production, genetically-determined regulatory abnormalities in proliferation and/or differentiation of B-1 cells may determine their fate. We earlier found that, in H-2-congenic (NZB x NZW) F1 mice, while...

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PMID: 9808571

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