Article
Susceptibility alleles for aberrant B-1 cell proliferation involved in spontaneously occurring B-cell chronic lymphocytic leukemia in a model of New Zealand white mice.
Blood - 15 Nov 1998
Hamano Y, Hirose S, Ida A, Abe M, Zhang D, Kodera S, Jiang Y, Shirai J, Miura Y, Nishimura H, Shirai T
Abstract excerpt
B-cell chronic lymphocytic leukemia (B-CLL) and autoimmune disease are a related event, and genetic factors are linked to both diseases. As B-CLL is mainly of B-1 cell type that participates in autoantibody production, genetically-determined regulatory abnormalities in proliferation and/or differ...
Topics
- Animals
- Autoimmune Diseases
- B-Lymphocytes
- Cell Division
- Cell Transformation, Neoplastic
- Chromosome Mapping
- Crosses, Genetic
- Female
- Genetic Predisposition to Disease
- Genotype
- H-2 Antigens
- Haplotypes
- Leukemia, Lymphocytic, Chronic, B-Cell
- Mice