Interleukin 6 is essential for in vivo development of B lineage neoplasms.

doi:10.1084/jem.182.1.243

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Article

Interleukin 6 is essential for in vivo development of B lineage neoplasms.

The Journal of experimental medicine - 1 Jul 1995

Hilbert D M, Kopf M, Mock B A, Köhler G, Rudikoff S

Abstract excerpt

Interleukin (IL) 6 has been suggested to be the major cytokine responsible for proliferation of neoplastic plasma cells in both human myeloma and mouse plasmacytoma. Much of the evidence supporting this suggestion is derived from in vitro studies in which the survival or proliferation of some plasma cell tumors has been found to be IL-6 dependent. However, it remains unclear whether this dependency is the...

Topics

Alleles
Animals
B-Lymphocytes
Base Sequence
Cell Division
Cocarcinogenesis
Crosses, Genetic
Female
Flow Cytometry
Gammaretrovirus
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Hybridization

Interleukin-6

Lymphoma, B-Cell

Lymphoma, T-Cell

Male

Mice

Source

Open in PubMed Open full text

Identifiers

PMID: 7790819
DOI: 10.1084/jem.182.1.243
PMCID: PMC2192088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7790819-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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