Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD4+ T lymphocytes with constitutive CD40 ligand in preautoimmune (NZB x NZW)F1 lupus-prone mice: phenotype and possible role in autoreactivity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2000

Lettesjö H, Burd G P, Mageed R A

Abstract excerpt

Lupus disease is marked by B lymphocyte hyperactivity and the production of Abs to dsDNA. The production of these anti-dsDNA Abs is T lymphocyte dependent. However, it is not clear how CD4+ T lymphocytes provide help for B lymphocytes to produce IgG anti-dsDNA Abs. One possible mechanism is suggested by studies showing that human patients with systemic lupus erythematosus and lupus mice have increased numbers of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Antinuclear
Share to Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD40 Ligand

Share to Cell Aggregation

Share to Immunization

Share to Lymphocyte Count

Share to Mice, Inbred CBA

Share to Mice, Inbred NZB

Source

Identifiers

PMID: 11034421
DOI: 10.4049/jimmunol.165.7.4095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD4+ T lymphocytes with constitutive CD40 ligand in preautoimmune (NZB x NZW)F1 lupus-prone mice: phenotype and possible role in autoreactivity.PMID 11034421Read ↗

Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW MiceSemantic proximity Read ↗

Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice. Response correlates with the absence of an anti-antibody responseSemantic proximity Read ↗

Establishment and characterization of cloned CD4- CD8- alphabeta-T cell receptor (TCR)-bearing autoreactive T cells from autoimmune NZB x NZW F1 mice.Semantic proximity Read ↗

B Cells Are Required for Lupus Nephritis in the Polygenic, Fas-Intact MRL Model of Systemic AutoimmunitySemantic proximity Read ↗

Distinct surface phenotypes of B cells responsible for spontaneous production of IgM and IgG anti-DNA antibodies in autoimmune-prone NZB x NZW F1 mice.Semantic proximity Read ↗

Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.Semantic proximity Read ↗

Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model.Semantic proximity Read ↗

Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains: possible involvement in systemic lupus erythematosus pathogenesis.Semantic proximity Read ↗

Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.Semantic proximity Read ↗

Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.Semantic proximity Read ↗

Changes in the cytokine profile of lupus-prone mice (NZB/NZW)F1 induced by Plasmodium chabaudi and their implications in the reversal of clinical symptoms.Semantic proximity Read ↗

IL-10 regulation of lupus in the NZM2410 murine model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.