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Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice

1 May 2000

Abstract excerpt

Since anti-CD1 TCR transgenic T cells can activate syngeneic B cells via CD1 to secrete IgM and IgG and induce lupus in BALB/c mice, we studied the role of CD1 in the pathogenesis of lupus in NZB/NZW mice. Approximately 20% of B cells from the spleens of NZB/NZW mice expressed high levels of CD1 (CD1high B cells). The latter subset spontaneously produced large amounts of IgM anti-dsDNA Abs in vitro that was up to...

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PMID: 10799851
DOI: 10.4049/jimmunol.164.10.5000

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