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Article

Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice

10 Mar 2007

Abstract excerpt

New Zealand black (NZB) mice with autoimmune and B lymphoproliferative disease (B-LPD) are a model for human chronic lymphocytic leukemia (CLL). A genomewide linkage scan of the NZB loci associated with lymphoma was conducted in F1 backcrosses of NZB and a control strain, DBA/2. Of 202 mice phenotyped for the presence or absence of LPD, surface maker expression, DNA content, and microsatellite polymorphisms, 74...

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PMID: 17351108
DOI: 10.1182/blood-2007-02-071225

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