Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.

doi:10.1084/jem.175.5.1213

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Article

Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.

The Journal of experimental medicine - 1 May 1992

Ishida H, Hastings R, Kearney J, Howard M

Abstract excerpt

Ly-1 B cells have the distinctive property of continuous self-replenishment and, as we have shown previously, can be further distinguished from conventional B cells on the basis of greatly elevated constitutive and inducible production of the recently described cytokine interleukin 10 (IL-10). To test the possibility that IL-10 acts as either an autocrine or paracrine growth factor for Ly-1 B cells, we treated...

Topics

Animals
Antibodies
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
B-Lymphocytes
CD3 Complex
Cell Division
Female
Fluorescent Antibody Technique
Immunoglobulin M
Injections, Intraperitoneal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-10

Lipopolysaccharides

Mice

Mice, Inbred BALB C

Mice, Inbred C3H

Neutralization Tests

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 1533240
DOI: 10.1084/jem.175.5.1213
PMCID: PMC2119200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1533240-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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