Article
Bone marrow transplantation from mutant lpr/lpr mice. Functional abnormalities rather than alloantigenic differences appear to determine the development of a graft-vs.-host-like syndrome.
European journal of immunology - 1 Sept 1990
Allen R D, Marshall J D, Roths J B, Sidman C L
Abstract excerpt
Transfer of bone marrow (BM) from autoimmunity-prone mice homozygous for the lymphoproliferation (lpr) mutation to irradiated congenic +/+ recipients has previously been shown to result in a syndrome similar to chronic graft-vs.-host (GVH) disease. It has been suggested that this syndrome may be due to an antigenic difference caused by the lpr mutation itself or to antigenic differences at loci closely linked to...
Topics
- Animals
- Autoimmune Diseases
- Bone Marrow Transplantation
- Graft vs Host Disease
- Immunoglobulin G
- Immunologic Deficiency Syndromes
- Interleukin-4
- Isoantigens
- Lymphoid Tissue
- Lymphoproliferative Disorders