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Murine models of chronic lymphocytic leukaemia: role of microRNA‐16 in the New Zealand Black mouse model

18 Oct 2007

Abstract excerpt

Mouse models are valuable tools in the study of human chronic lymphocytic leukaemia (CLL). The New Zealand Black (NZB) strain is a naturally occurring model of late-onset CLL characterized by B-cell hyperproliferation and autoimmunity early in life, followed by progression to CLL. Other genetically engineered models of CLL that have been developed include (NZB x NZW) F1 mice engineered to express IL5, mice...

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PMID: 17941951
DOI: 10.1111/j.1365-2141.2007.06851.x

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