Article
Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan.
Biochemical and biophysical research communications - 31 Mar 1992
Kondo K, Umemoto A, Akimoto S, Uyama T, Hayashi K, Ohnishi Y, Monden Y
Abstract excerpt
The reverse transcription-polymerase chain reaction-single strand conformation polymorphism (RT-PCR-SSCP) analysis and sequencing were used to examine p53 gene alterations in 18 surgical specimens of primary lung cancers obtained in Japan. Somatic mutations resulting in amino acid changes were fo...
Topics
- Adenocarcinoma
- Base Sequence
- Carcinoma
- Genes, Tumor Suppressor
- Humans
- Japan
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Smoking
- Tumor Suppressor Protein p53