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Article

Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan.

Biochemical and biophysical research communications - 31 Mar 1992

Kondo K, Umemoto A, Akimoto S, Uyama T, Hayashi K, Ohnishi Y, Monden Y

Abstract excerpt

The reverse transcription-polymerase chain reaction-single strand conformation polymorphism (RT-PCR-SSCP) analysis and sequencing were used to examine p53 gene alterations in 18 surgical specimens of primary lung cancers obtained in Japan. Somatic mutations resulting in amino acid changes were found in eight of the 18 cases (44%). Seven missense mutations were located in amino acid-conserved domains or their...

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Identifiers

PMID: 1348931
DOI: 10.1016/s0006-291x(05)80309-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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