Article
Alteration of p53 gene structure and function in laryngeal squamous cell cancer.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 1 Jan 1997
Golusinski W, Olofsson J, Szmeja Z, Szyfter K, Szyfter W, Biczysko W, Hemminki K
Abstract excerpt
The p53 gene is known as an anti-oncogene that manifests its function by controlling the cell cycle and is responsible for apoptosis of cells with unrepaired DNA. An accelerated p53 protein synthesis is the first response of a cell following DNA damage. However, mutations of the p53 gene can dist...
Topics
- Adult
- Aged
- Aged, 80 and over
- Apoptosis
- Base Sequence
- Carcinoma, Squamous Cell
- Cell Cycle
- Cell Division
- Coloring Agents
- DNA
- DNA, Neoplasm
- Exons
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Immunohistochemistry
- Ki-67 Antigen