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Article

Tumor suppressor activity of the TGF-beta pathway in human cancers.

Cytokine & growth factor reviews - 1 Jun 1996

Markowitz S D, Roberts A B

Abstract excerpt

The TGF-betas are a family of cytokines with antiproliferative activity on many cell types. Recent findings demonstrate that the TGF-beta receptor complex functions as a tumor suppressor gene in human malignancy. Somatic mutations of the type II subunit of the TGF-beta receptor (RII) have been demonstrated in several different tumor types. RII frameshift mutations within a short coding region polyadenine repeat...

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Identifiers

PMID: 8864357
DOI: 10.1016/1359-6101(96)00001-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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