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Article

Type III TGF-β Receptor Enhances Colon Cancer Cell Migration and Anchorage-Independent Growth

1 Aug 2011

Abstract excerpt

The type III TGF-β receptor (TβRIII or betagylcan) is a TGF-β superfamily coreceptor with emerging roles in regulating TGF-β superfamily signaling and cancer progression. Alterations in TGF-β superfamily signaling are common in colon cancer; however, the role of TβRIII has not been examined. Although TβRIII expression is frequently lost at the message and protein level in human cancers and suppresses cancer...

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PMID: 21847367
DOI: 10.1593/neo.11528

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