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Article

Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis.

Cytokine & growth factor reviews - 1 Jan 2000

Kim S J, Im Y H, Markowitz S D, Bang Y J

Abstract excerpt

Signals from the TGF-betas are mediated by the TGF-beta receptors and their substrates, the Smad proteins. Inactivation of either of the two transmembrane serine/threonine kinases called the TGF-beta type I and type II receptors is now known to underlie a wide variety of human pathologies including, especially carcinogenesis. Numerous studies have now demonstrated that the TGF-beta receptor complex and its...

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PMID: 10708963
DOI: 10.1016/s1359-6101(99)00039-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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