Article
Transfection of the type II TGF-beta receptor into colon cancer cells increases receptor expression, inhibits cell growth, and reduces the malignant phenotype.
Annals of surgery - 1 Jun 1998
MacKay S L, Auffenberg T, Tannahill C L, Ksontini R, Josephs M D, Nowak M, Moldawer L L, Copeland E M
Abstract excerpt
OBJECTIVE: To determine if transfection of SW48 colon cancer cells with the type II transforming growth factor-beta (TGF-beta) receptor restores growth inhibition and reverses the in vitro and in vivo malignant phenotype. SUMMARY BACKGROUND DATA: The authors have previously shown that SW48 colon cancer cells that are replication error positive in both alleles lack functional cell surface TGF-beta type I (RI) and...
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