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Article

Expression of the type III TGF-β receptor is negatively regulated by TGF-β

24 Feb 2008

Abstract excerpt

The type III transforming growth factor-beta receptor (TbetaRIII or betaglycan) is a ubiquitously expressed transforming growth factor-beta (TGF-beta) superfamily coreceptor with essential roles in embryonic development. Recent studies have defined a role for TbetaRIII in the pathogenesis of human cancers, with frequent loss of TbetaRIII expression at the message and protein level. Mechanisms for the loss of...

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PMID: 18299279
DOI: 10.1093/carcin/bgn049

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