Effects of P2 cleavage site mutations on poliovirus polyprotein processing.

doi:10.1006/viro.1996.0504

Back to search

Article

Effects of P2 cleavage site mutations on poliovirus polyprotein processing.

Virology - 1 Oct 1996

Cohen L, Kean K M, Girard M, Van der Werf S

Abstract excerpt

The poliovirus genome comprises a single open reading frame which is translated to give one large polyprotein. The proteolytic cascade involved in the processing of this polyprotein is not yet understood in full detail,particularly concerning the processing of P2-P3, the precursor to the viral no...

Topics

Binding Sites
HeLa Cells
Humans
Mutagenesis, Site-Directed
Mutation
Poliovirus
Protein Precursors
Protein Processing, Post-Translational
Proteins
RNA, Viral
Viral Proteins

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.