Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing.

doi:10.1128/JVI.73.10.8083-8094.1999

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Article

Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing.

Journal of virology - 1 Oct 1999

Amberg S M, Rice C M

Abstract excerpt

Analysis of flavivirus polyprotein processing has revealed the presence of a substrate for the virus-encoded NS2B-NS3 protease at the carboxy-terminal end of the C (capsid or core) protein. Cleavage at this site has been implicated in the efficient generation of the amino terminus of prM via signal peptidase cleavage. Yellow fever virus has four basic residues (Arg-Lys-Arg-Arg) in the P1 through P4 positions of...

Topics

Capsid
Flavivirus
Mutation
Protein Processing, Post-Translational
RNA Helicases
Serine Endopeptidases
Viral Nonstructural Proteins

Source

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Identifiers

PMID: 10482557
DOI: 10.1128/JVI.73.10.8083-8094.1999
PMCID: PMC112824

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