Article
Cleavage specificity of the poliovirus 3C protease is not restricted to Gln-Gly at the 3C/3D junction.
The Journal of general virology - 1 Nov 1990
Kean K M, Teterina N, Girard M
Abstract excerpt
The 3C protease of poliovirus is distinguished from that of all other picornaviruses in that it only cleaves at Gln-Gly amino acid pairs within the viral polyprotein. To determine whether this strict cleavage specificity is an intrinsic property of the poliovirus 3C protease, amino acid substitut...
Topics
- 3C Viral Proteases
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Cysteine Endopeptidases
- DNA, Viral
- HeLa Cells
- Humans
- Hydrolysis
- Molecular Sequence Data
- Moths
- Mutagenesis, Site-Directed
- Phenotype
- Poliovirus
- Substrate Specificity
- Viral Proteins