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Article

Cleavage specificity of the poliovirus 3C protease is not restricted to Gln-Gly at the 3C/3D junction.

The Journal of general virology - 1 Nov 1990

Kean K M, Teterina N, Girard M

Abstract excerpt

The 3C protease of poliovirus is distinguished from that of all other picornaviruses in that it only cleaves at Gln-Gly amino acid pairs within the viral polyprotein. To determine whether this strict cleavage specificity is an intrinsic property of the poliovirus 3C protease, amino acid substitutions were introduced at one of the Gln-Gly cleavage sites. Oligonucleotide-directed site-specific mutagenesis of an...

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Source

Identifiers

PMID: 2174954
DOI: 10.1099/0022-1317-71-11-2553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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