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Article

Defective RNA replication by poliovirus mutants deficient in 2A protease cleavage activity.

Journal of virology - 1 Jan 1995

Yu S F, Benton P, Bovee M, Sessions J, Lloyd R E

Abstract excerpt

2A protease (2Apro) catalyzes the initial cleavage of the poliovirus polyprotein which separates the P1 structural protein precursor from the P2-P3 nonstructural protein precursor. In addition, 2Apro indirectly induces cleavage of the p220 component of eukaryotic initiation factor 4F, which is thought to contribute to the specific inhibition of host cell protein synthesis observed in virus-infected HeLa cells....

Topics

Animals
Cells, Cultured
Cysteine Endopeptidases
HeLa Cells
Humans
Hydrolysis
Mutation
Poliovirus
Protein Processing, Post-Translational
RNA, Viral
Transfection
Viral Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7983716
DOI: 10.1128/JVI.69.1.247-252.1995
PMCID: PMC188570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7983716-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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