Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modifications to the Foot-and-Mouth Disease Virus 2A Peptide: Influence on Polyprotein Processing and Virus Replication.

Journal of virology - 15 Apr 2018

Kjær Jonas, Belsham Graham J

Abstract excerpt

Foot-and-mouth disease virus (FMDV) has a positive-sense single-stranded RNA (ssRNA) genome that includes a single, large open reading frame encoding a polyprotein. The cotranslational "cleavage" of this polyprotein at the 2A/2B junction is mediated by the 2A peptide (18 residues in length) using a nonproteolytic mechanism termed "ribosome skipping" or "StopGo." Multiple variants of the 2A polypeptide with this...

Topics

Animals
Cell Line
Cricetinae
Foot-and-Mouth Disease Virus
Mutation
Polyproteins
Protein Biosynthesis
Protein Processing, Post-Translational
Viral Proteins
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 29386286
DOI: 10.1128/JVI.02218-17
PMCID: PMC5874415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29386286-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modifications to the Foot-and-Mouth Disease Virus 2A Peptide: Influence on Polyprotein Processing and Virus Replication.PMID 29386286Read ↗

Determinants of the VP1/2A junction cleavage by the 3C protease in foot-and-mouth disease virus-infected cells.Semantic proximity Read ↗

Insights into polyprotein processing and RNA-protein interactions in foot-and-mouth disease virus genome replicationSemantic proximity Read ↗

Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways.Semantic proximity Read ↗

Identification of a short, highly conserved, motif required for picornavirus capsid precursor processing at distal sitesSemantic proximity Read ↗

The ‘cleavage’ activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring ‘2A-like’ sequencesSemantic proximity Read ↗

Low levels of foot-and-mouth disease virus 3C protease expression are required to achieve optimal capsid protein expression and processing in mammalian cellsSemantic proximity Read ↗

2A and 2A-like Sequences: Distribution in Different Virus Species and Applications in BiotechnologySemantic proximity Read ↗

Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elementsSemantic proximity Read ↗

Foot‐and‐mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein.Semantic proximity Read ↗

Picornavirus Evolution: Genomes Encoding Multiple 2A<sup>NPGP</sup> Sequences – Biomedical and Biotechnological UtilitySemantic proximity Read ↗

Molecular architecture and diversity of StopGo/2A translational recodingSemantic proximity Read ↗

Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule FormationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.