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Article

Poliovirus capsid proteins derived from P1 precursors with glutamine-valine cleavage sites have defects in assembly and RNA encapsidation.

Journal of virology - 1 Dec 1993

Ansardi D C, Morrow C D

Abstract excerpt

Assembly of poliovirus virions requires proteolytic cleavage of the P1 capsid precursor polyprotein between two separate glutamine-glycine (QG) amino acid pairs by the viral protease 3CD. In this study, we have investigated the effects on P1 polyprotein processing and subsequent assembly of processed capsid proteins caused by substitution of the glycine residue at the individual QG cleavage sites with valine...

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Identifiers

PMID: 8230452
DOI: 10.1128/JVI.67.12.7284-7297.1993
PMCID: PMC238192

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