Article
Poliovirus capsid proteins derived from P1 precursors with glutamine-valine cleavage sites have defects in assembly and RNA encapsidation.
Journal of virology - 1 Dec 1993
Ansardi D C, Morrow C D
Abstract excerpt
Assembly of poliovirus virions requires proteolytic cleavage of the P1 capsid precursor polyprotein between two separate glutamine-glycine (QG) amino acid pairs by the viral protease 3CD. In this study, we have investigated the effects on P1 polyprotein processing and subsequent assembly of proce...
Topics
- 3C Viral Proteases
- Amino Acid Sequence
- Base Sequence
- Capsid
- Cysteine Endopeptidases
- Genetic Complementation Test
- Genome, Viral
- Glutamine
- HeLa Cells
- Humans
- Molecular Sequence Data
- Morphogenesis
- Mutation
- Poliovirus
- Protein Precursors
- Protein Processing, Post-Translational
- RNA, Viral
- Recombinant Proteins