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Article

A mutant poliovirus containing a novel proteolytic cleavage site in VP3 is altered in viral maturation.

Journal of virology - 1 Apr 1990

Blair W S, Hwang S S, Ypma-Wong M F, Semler B L

Abstract excerpt

A six-amino-acid insertion containing a Q-G amino acid pair was introduced into the carboxy terminus of the capsid protein VP3 (between residues 236 and 237). Transfection of monkey cells with full-length poliovirus cDNA containing the insertion described above yields a mutant virus (Sel-1C-02) in which cleavage occurs almost entirely at the inserted Q-G amino acid pair instead of at the wild-type VP3-VP1...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 2157059
DOI: 10.1128/JVI.64.4.1784-1793.1990
PMCID: PMC249316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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