Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants.

Abstract excerpt

A poliovirus (PV) mutant (termed GG), which is incapable of producing 3AB, VPg, and 3CD proteins due to a defective cleavage site between the 3B and 3C proteins, replicated, producing 3BC-linked RNA rather than the VPg-linked RNA produced by the wild type (WT). GG PV RNA is quasi-infectious. The yield of infectious GG PV relative to replicated RNA is reduced by almost 5 logs relative to that of WT PV. Proteolytic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genome, Viral
• Share to Mutation
• Share to Poliovirus