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Article

Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.

Journal of virology - 1 May 1990

Kräusslich H G, Hölscher C, Reuer Q, Harber J, Wimmer E

Abstract excerpt

The poliovirus polyprotein is cotranslationally linked to myristic acid at its amino-terminal glycine residue. We investigated the role of myristoylation in the viral replication cycle by site-directed mutagenesis of this glycine codon. Synthetic full-length RNA transcripts carrying a Gly-to-Ala mutation (G4002A) gave no infectious virus on transfection into permissive cells (HeLa). However, mutant viral RNA was...

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Identifiers

PMID: 2157900
DOI: 10.1128/JVI.64.5.2433-2436.1990
PMCID: PMC249411

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Source receipt: pubmed, retrieved 7 Sept 2026.

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