Cytochrome P450: genetic polymorphism and drug interactions.

doi:10.1080/22953337.1996.11718518

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Article

Cytochrome P450: genetic polymorphism and drug interactions.

Acta clinica Belgica - 1 Jan 1996

Belpaire F M, Bogaert M G

Abstract excerpt

In this review, after a short discussion of our knowledge about cytochrome P450 isoenzymes, two important sources of variability in the metabolism of drugs by cytochrome P450 are described, i.e. genetic factors and drug-drug interactions. Many hepatic cytochrome P450 enzymes play an important rol...

Topics

Biotransformation
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Drug Interactions
Genotype
Humans
Isoenzymes
Oxidation-Reduction
Pharmaceutical Preparations
Phenotype
Polymorphism, Genetic

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