Article
Cytochrome P450: genetic polymorphism and drug interactions.
Acta clinica Belgica - 1 Jan 1996
Belpaire F M, Bogaert M G
Abstract excerpt
In this review, after a short discussion of our knowledge about cytochrome P450 isoenzymes, two important sources of variability in the metabolism of drugs by cytochrome P450 are described, i.e. genetic factors and drug-drug interactions. Many hepatic cytochrome P450 enzymes play an important role in the oxidative biotransformation of numerous drugs and other foreign compounds, and of many endogenous substrates....
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