Article
[Genetic polymorphism in human drug metabolism].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica - 1 Feb 1993
Yamazoe Y, Nagata K
Abstract excerpt
During the last decade, the influences of genetic factors on individual drug metabolizing capacity in humans have been characterized in fairly great detail at the molecular level. Debrisoquine/sparteine and mephenytoin polymorphisms are now known to be derived from defects in the human liver of s...
Topics
- Cytochrome P-450 Enzyme System
- Humans
- Lung Neoplasms
- Microsomes, Liver
- Pharmaceutical Preparations
- Phenotype
- Polymorphism, Genetic