Genetically determined adverse drug reactions involving metabolism.

doi:10.2165/00002018-199309010-00006

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Article

Genetically determined adverse drug reactions involving metabolism.

Drug safety - 1 Jul 1993

Lennard M S

Abstract excerpt

Genetic factors represent an important source of interindividual variation in drug response. Relatively few adverse drug effects with a pharmacodynamic basis are known, and most of the well characterised inherited traits take the form of genetic polymorphisms of drug metabolism. Monogenic control...

Topics

Acetylation
Cytochrome P-450 Enzyme System
Drug-Related Side Effects and Adverse Reactions
Humans
Methylation
Oxidation-Reduction
Pharmaceutical Preparations
Phenotype
Polymorphism, Genetic
Risk Factors

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