Article

Pharmacogenetic Variation in Drug Oxidizing CYPs: Impact on Drug Therapy, Drug Safety and Drug Interactions.

2003-09-01

Abstract excerpt

Cytochromes P450 (CYPs) are multifunctional enzymes that are active in the oxidative metabolism of many drugs and play a dominant role in the elimination of drugs from the body. Pharmacokinetic interactions may arise when the biotransformation and elimination of a drug are impaired by coadministered drugs. Thus, drugs may compete for biotransformation by a common CYP. Adverse drug reactions, including toxicity, ca...

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Literature Corpus work: 21abe787-9e3f-502b-bcd0-79798356d2de
DOI: 10.2174/1570160033476250

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