Pharmacogenetics of the Cytochrome P450 Enzyme System: Review of Current Knowledge and Clinical Significance

Abstract excerpt

Genetic variation in drug metabolizing enzymes is an important contributor to interindividual variation in drug disposition and response and is associated with significant clinical consequences. Many commonly used drugs are dependent on the cytochrome P450 monooxygenase enzymes (CYP450) for their metabolism and elimination. At present, more than 57 active human CYP450 genes are known, and the majority of these gen...

Topics

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• Computational Drug Discovery Methods
• Drug Transport and Resistance Mechanisms
• Pharmacogenetics and Drug Metabolism

Identifiers and source

Literature Corpus work

a1f01ce6-a1b7-5296-a329-73df54cf98ec

DOI

10.1177/0897190007304821